Which auxiliary label advises against consuming grapefruit?

The auxiliary label that advises against consuming grapefruit is associated with amiodarone, as grapefruit juice can significantly affect the metabolism of certain medications. Amiodarone, which is used for treating arrhythmias, is metabolized by the liver's cytochrome P450 enzymes, particularly CYP3A4. Grapefruit juice inhibits this enzyme, leading to increased levels of the medication in the bloodstream, which can escalate the risk of side effects and toxicity.

While simvastatin is also another medication known to interact with grapefruit, the specific question focuses on the auxiliary label that explicitly warns against grapefruit consumption, which applies to amiodarone. Medications like ibuprofen and metformin do not have this particular interaction with grapefruit and do not require such a warning. This distinction helps ensure patient safety when taking medications that can undergo altered metabolism due to dietary choices.